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2024
The human Y and inactive X chromosomes similarly modulate autosomal gene expression
San Roman AK, Skaletsky H, Godfrey AK, Bokil N, Teitz L, Singh I, Blanton LV, Bellott DW, Pyntikova T, Lange J, Koutseva N, Hughes JF, Brown LG, Phou S, Buscetta A, Kruszka P, Banks N, Dutra A, Pak E, Lasutschinkow PC, Keen C, Davis SM, Lin AE, Tartaglia NR, Samango-Sprouse C, Muenke M, Page DC
Cell Genomics 4, 100462 (2024); Supplementary Information
Related news items: Cell Genomics The Tech Whitehead
2023
Human microglia maturation is underpinned by specific gene regulatory networks
Han CZ, Li RZ, Hansen E, Trescott S, Fixsen BR, Nguyen CT, Mora CM, Spann NJ, Bennett HR, Poirion O, Buchanan J, Warden AS, Xia B, Schlachetzki JCM, Pasillas MP, Preissl S, Wang A, O'Connor C, Shriram S, Kim R, Schafer D, Ramirez G, Challacombe J, Anavim SA, Johnson A, Gupta M, Glass IA; Birth Defects Research Laboratory; Levy ML, Haim SB, Gonda DD, Laurent L, Hughes JF, Page DC, Blurton-Jones M, Glass CK, Coufal NG
Immunity 56, 1 (2023); Supplementary Information
Cell type-specific role of CBX2 and its disordered region in spermatogenesis
Kim JJ, Steinson ER, Lau MS, de Rooij DG, Page DC, Kingston RE
Genes Dev 37, 640 (2023); Supplementary Information
Efficient in vivo genome editing prevents hypertrophic cardiomyopathy in mice
Reichart D, Newby GA, Wakimoto H, Lun M, Gorham JM, Curran JJ, Raguram A, DeLaughter DM, Conner DA, Marsiglia JDC, Kohli S, Chmatal L, Page DC, Zabaleta N, Vandenberghe L, Liu DR, Seidman JG, Seidman C
Nat Med 29, 412 (2023); Supplementary Information
Related news item: Nature Medicine
The human inactive X chromosome modulates expression of the active X chromosome
San Roman AK, Godfrey AK, Skaletsky H, Bellott DW, Groff AF, Harris HL, Blanton LV, Hughes JF, Brown LG, Phou S, Buscetta A, Kruszka P, Banks N, Dutra A, Pak E, Lasutschinkow PC, Keen C, Davis SM, Tartaglia NR, Samango-Sprouse C, Muenke M, Page DC
Cell Genomics 3, 100259 (2023); Supplementary Information
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2022
Bellott DW, Cho TJ, Jackson EK, Skaletsky H, Hughes JF, Page DC
PLOS One 17, e0269692 (2022); Supplementary Information
Hughes JF, Skaletsky H, Nicholls P, Drake A, Pyntikova T, Cho TJ, Bellott DW, Page DC
BMC Biol 20, 133 (2022); Supplementary Information
Genetic characterization of a missense mutation in the X-linked TAF7L gene identified in an oligozoospermic man
Ling L, Li F, Yang P, Oates RD, Silber S, Kurischko C, Luca FC, Leu NA, Zhang J, Yue Q, Skaletsky H, Brown LG, Rozen S,
Page DC, Wang PJ, Zheng K
Biol Reprod 107, 157 (2022); Supplementary Information
2021
Jackson EK, Bellott DW, Skaletsky H, Page DC
G3 11, jkab224 (2021); Supplementary Information
Large palindromes on the primate X chromosome are preserved by natural selection
Jackson EK, Bellot DW, Cho TJ, Skaletsky H, Hughes JF, Pyntikova T, Page DC
Genome Res 31, 1337 (2021); Supplementary Information
Germ cell determination and the developmental origin of germ cell tumors
Nicholls PK, Page DC
Development 148, dev198150 (2021)
Bellott DW, Page DC
Genome Res 31, 198 (2021); Supplementary Information
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2020
Sequence analysis in Bos taurus reveals pervasiveness of X-Y arms races in mammalian lineages
Hughes JF, Skaletsky H, Pyntikova T, Koutseva N, Raudsepp T, Brown LG, Bellot DW, Cho TJ, Dugan-Rocha S, Khan Z, Kremitzki C, Fronick C, Graves-Lindsay TA, Fulton L, Warren WC, Wilson RK, Owens E, Womack JE, Murphy WJ, Muzny DM, Worley KC, Chowdhary BP, Gibbs RA, Page DC
Genome Res 30, 1716 (2020); Supplementary Information
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Mikedis MM, Fan Y, Nicholls PK, Endo T, Jackson EK, Cobb SA, de Rooij DG, Page DC
eLife 9, e56523 (2020)
Quantitative analysis of Y-chromosome gene expression across 36 human tissues
Godfrey AK, Naqvi S, Chmatal L, Chick JM, Mitchell RN, Gygi SP, Skaletsky H, Page DC
Genome Res 30, 860 (2020); Supplementary Information
Dynamic and regulated TAF gene expression during mouse embryonic germ cell development
Gura MA, Mikedis MM, Seymour KA, de Rooij DG, Page DC, Freiman RN
PLOS Genet 16, e1008515 (2020); Supplementary Information
GCNA interacts with spartan and topoisomerase II to regulate genome stability
Dokshin GA, Davis GM, Sawle AD, Eldridge MD, Nicholls PK, Gourley TE, Romer KA, Molesworth LW, Tatnell HR, Ozturk AR, de Rooij DG, Hannon GJ, Page DC, Mello CC, Carmell MA
Dev Cell 52, 53 (2020); Supplementary Information
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2019
Mammalian germ cells are determined after PGC colonization of the nascent gonad
Nicholls PK, Schorle H , Naqvi S, Hu YC, Fan Y, Carmell MA, Dobrinski I, Watson AL, Carlson DF, Fahrenkrug SC, Page DC PNAS 116, 25677 (2019); Supplementary Information
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Retinoic acid and germ cell development in the ovary and testis
Endo T, Mikedis MM, Nicholls PK, Page DC, de Rooij DG
Biomolecules 9, 775 (2019)
Circle of Willis anomalies in Turner syndrome: Absent A1 segment of the anterior cerebral artery.
Kruszka P, Buscetta A, Acosta MT, Banks N, Addissie YA, Toro C, Luby M, Latour L, Vezina G, Page DC, Muenke M.
Birth Defects Res 111:1584 (2019)
Conservation, acquisition, and functional impact of sex-biased gene expression in mammals
Naqvi S, Godfrey AK, Hughes JF, Goodheart ML, Mitchell RN, Page DC
Science 365, eaaw7317 (2019); Supplementary Information Processed Data and Code
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Intergenerational epigenetic inheritance of cancer susceptibility in mammals
Lesch BJ, Tothova Z, Morgan EA, Liao Z, Bronson RT, Ebert BL, Page DC
eLife 8, e39380 (2019); Supplementary Information
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Locating and characterizing a transgene integration site by nanopore sequencing
Nicholls PK, Bellott DW, Cho TJ, Pyntikova T, Page DC
G3 9, 1481 (2019); Supplementary Information
Chromosome segregation errors generate a diverse spectrum of simple and complex genomic rearrangements
Ly P, Brunner SF, Shoshani O, Kim DH, Lan W, Pyntikova T, Flanagan AM, Behjati S, Page DC, Campbell PJ, Cleveland DW
Nat Genet 51,705 (2019); Supplementary Information
Amplification of a broad transcriptional program by a common factor triggers the meiotic cell cycle in mice
Kojima ML, de Rooij DG, Page DC
eLife 8, e43738 (2019); Supplementary Information
A strategic research alliance: Turner syndrome and sex differences
San Roman AK, Page DC
Am J Med Genet C 181, 59 (2019)
2018
Romer KA, De Rooij DG, Kojima ML, Page DC
Dev Biol 443, 19 (2018); Supplementary Information
Teitz LS, Pyntikova T, Skaletsky H, Page DC
Am J Hum Genet 103, 261 (2018); Supplementary Information
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Bellott DW, Cho TJ, Hughes JF, Skaletsky H, Page DC
Nat Protoc 13, 787 (2018); Supplementary Information
Naqvi S, Bellott DW, Lin KS, Page DC
Genome Res 28, 474 (2018); Supplementary Information
2017
Periodic production of retinoic acid by meiotic and somatic cells coordinates four transitions in mouse spermatogenesis
Endo T, Freinkman E, de Rooij DG, Page DC
PNAS 114, E10132 (2017); Supplementary Information
Intrinsic fertility of human oocytes
Silber SJ, Kato K, Aoyama N, Yabuuchi A, Skaletsky H, Fan Y, Shinohara K, Yatabe N, Kobayashi T
Fertil Steril 107, 1232 (2017)
Meioc maintains an extended meiotic prophase I in mice
Soh YQS, Mikedis MM, Kojima M, Godfrey AK, de Rooij DG, Page DC
PLOS Genet 13, e1006704 (2017)
Avian W and mammalian Y chromosomes convergently retained dosage-sensitive regulators
Bellott DW, Skaletsky H, Cho TJ, Brown L, Locke D, Chen N, Galkina S, Pyntikova T, Koutseva N, Graves T, Kremitzki C, Warren WC, Clark AG, Gaginskaya E, Wilson RK, Page DC
Nat Genet 49, 387 (2017); Supplementary Information
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Selective Y centromere inactivation triggers chromosome shattering in micronuclei and repair by non-homologous end joining
Ly P, Teitz LS, Kim DH, Shoshani O, Skaletsky H, Fachinetti D, Page DC, Cleveland DW
Nat Cell Biol 19, 68 (2017)
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2016
A widely employed germ cell marker is an ancient disordered protein with reproductive functions in diverse eukaryotes
Carmell MA, Dokshin GA, Skaletsky H, Hu YC, von Wolfswinkel JC, Igarashi KJ, Bellott DW, Nefedov M, Reddien PW, Enders GC, Uversky VN, Mello CC, Page DC
eLife 5, e19993 (2016); Supplementary Information
Parallel evolution of male germline epigenetic poising and somatic development in animals
Lesch BJ, Silber SJ, McCarrey JR, Page DC
Nat Genet 48, 888 (2016); Supplementary Information
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The history of the Y chromosome in man
Hughes JF, Page DC
Nat Genet 48, 588 (2016)
A mitotic SKAP isoform regulates spindle positioning at astral microtubule plus ends
Kern DM, Nicholls PK, Page DC, Cheeseman IM
J Cell Biol 213, 315 (2016); Supplementary Information
Related news items: JCB
2015
The biology and evolution of mammalian Y chromosomes
Hughes JF, Page DC
Annu Rev Genet 49, 507 (2015)
A gene regulatory program for meiotic prophase in the fetal ovary
Soh YQS, Junker JP, Gill ME, Mueller JL, van Oudenaarden A, Page DC
PLOS Genet 17, e1005531 (2015); Supplementary Information
The genome of the vervet (Chlorocebus aethiops sabaeus)
Warren WC, Jasinska AJ, Garcia-Perez R, Svardal H, Tomlinson C, Rocchi M, Archidiacono N, Capozzi O, Minx P, Montague MJ, Kyung K, Hillier LW, Kremitzki M, Graves T, Chiang C, Hughes JF, Tran N, Wang Y, Ramensky V, Choi OW, Jung YJ, Schmitt CA, Juretic N, Wasserscheid J, Turner TR, Wiseman RW, Tuscher JJ, Karl JA, Schmitz JE, Zahn R, O'Connor DH, Redmond E, Nisbett A, Jacquelin B, Müller-Trutwin MC, Brenchley JM, Dione M, Antonio M, Schroth GP, Kaplan JR, Jorgensen MJ, Thomas GW, Hahn MW, Raney B, Aken B, Schmitz J, Churakov G, Noll A, Stanyon R, Webb D, Thibaud-Nissen F, Nordborg M, Marques-Bonet T, Dewar K, Weinstock GM, Wilson RK, Freimer NB
Genome Res 25, 1921 (2015); Supplementary Information
Yang F, Silber S, Leu NA, Oates RD, Marszalek JD, Skaletsky H, Brown LG, Rozen S, Page DC, Wang PJ
EMBO Mol Med 7, 1198 (2015); Supplementary Information
Sex chromosome-to-autosome transposition events counter Y-chromosome gene loss in mammals
Hughes JF, Skaletsky H, Koutseva N, Pyntikova T, and Page DC
Genome Biol 16, 104 (2015); Supplementary Information
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Proceedings from the Turner Resource Network symposium: The crossroads of health care research and health care delivery
Backeljauw PF, Bondy C, Chernausek SD, Cernich JT, Cole DA, Fasciano LP, Foodim J, Hawley S, Hong DS, Knickmeyer RC, Kruszka P, Lin AE, Lippe BM, Lorigan GA, Maslen CL, Mauras N, Page DC, Pemberton VL, Prakash SK, Quigley CA, Ranallo KC, Reiss AL, Sandberg DE, Scurlock C, Silberbach M
Am J Med Genet A 167A, 1962 (2015)
Periodic retinoic acid-STRA8 signaling intersects with periodic germ-cell competencies to regulate spermatogenesis.
Endo T, Romer KA, Anderson EL, Baltus AE, de Rooij DG, Page DC
PNAS 112, E2347 (2015); Supplementary Information
Licensing of primordial germ cells for gametogenesis depends on genital ridge signaling
Hu YC, Nicholls PK, Soh YQ, Daniele JR, Junker JP, van Oudenaarden A, Page DC
PLOS Genet 11, e1005019 (2015); Supplementary Information
2014
Excess cholesterol induces mouse egg activation and may cause female infertility
Yesilaltay A, Dokshin GA, Bussoc D, Wang L, Galiani D, Chavarria T, Vasile E, Quilaqueo L, Orellana JA, Walzer D, Shalgi R, Dekel N, Albertini DF, Rigotti A, Page DC, and Krieger M
PNAS 111, E1972 (2014); Supplementary Information
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Sequencing the mouse Y chromosome reveals convergent gene acquisition and amplification on both sex chromosomes
Soh YQS, Alföldi J, Pyntikova T, Brown LG, Graves T, Minx PJ, Fulton RS, Kremitzki C, Koutseva N, Mueller JL, Rozen S, Hughes JF, Owens E, Womack JE, Murphy WJ, Cao Q, de Jong P, Warren WC, Wilson RK, Skaletsky H, Page DC
Cell 159, 800 (2014); Supplementary Information
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The E2 ubiquitin conjugating enzyme UBE2J1 is required for spermiogenesis in mice
Koenig PA, Nicholls PK, Schmidt FI, Hagiwara M, Maruyama T, Frydman GH, Watson N, Page DC, Ploegh HL
J Biol Chem 289, 34490 (2014); Supplementary Information
Poised chromatin in the mammalian germ line
Lesch BJ, Page DC
Development 141, 3619 (2014)
Retinoic acid activates two pathways required for meiosis in mice
Koubova J, Hu YC, Bhattacharyya T, Soh YQS, Gill ME, Goodheart ML, Hogarth CA, Griswold MD, Page DC
PLOS Genet 10, e004541 (2014); Supplementary Information
The common marmoset genome provides insight into primate biology and evolution
The Marmoset Genome Sequencing and Analysis Consortium
Nat Genet 46, 850 (2014); Supplementary Information
A chromatin-dependent role of the fragile X mental retardation protein FMRP in the DNA damage response
Alpatov R, Lesch BJ, Nakamoto-Kinoshita M, Blanco A, Chen S, Stutzer A, Armache KJ, Simon MD, Xu C, Ali M, Murn J, Prisic S, Kutateladze TG, Vakoc CR, Min J, Kingston RE, Rischle W, Warren ST, Page DC, Shi Y
Cell 157, 869 (2014); Supplementary Information
Mammalian Y chromosomes retain widely expressed, dosage-sensitive regulators
Bellott DW, Hughes JF, Skaletsky H, Brown LG, Pyntikova T, Cho TJ, Koutseva N, Zaghlul S, Graves T, Rock S, Kremitzki C, Fulton RS, Dugan S, Ding Y, Morton D, Khan Z, Lewis L, Buhay C, Wang Q, Watt J, Holder M, Lee S, Nazareth L, Alfoldi J, Rozen S, Muzny DM, Warren WC, Gibbs RA, Wilson RK, Page DC
Nature 508, 494 (2014); Supplementary Information
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2013
No bull: Upholding community standards in public sharing of biological datasets
Hughes JF, Skaletsky H, Bellott DW, Chowdhary BP, Warren WC, Worley KC, Wilson RK, Gibbs RA, Page DC
PNAS 110, E4277 (2013)
A set of genes critical to development is epigenetically poised in mouse germ cells from fetal stages through completion of meiosis
Lesch BJ, Dokshin GA, Young RA, McCarrey JR, Page DC
PNAS 110, 16061 (2013); Supplementary Information
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Independent specialization of the human and mouse X chromosomes for the male germ line
Mueller JL, Skaletsky H, Brown LG, Zaghlul S, Rock S, Graves T, Auger K, Warren WC, Wilson RK, Page DC
Nat Genet 45, 1083 (2013); Supplementary Information
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Tumor suppressor gene Rb is required for self-renewal of spermatogonial stem cells in mice
Hu YC, de Rooij DG, Page DC
PNAS 110, 12685 (2013); Supplementary Information
Gata4 is required for formation of the genital ridge in mice
Hu YC, Okumura LM, Page DC
PLOS Genet 9, e1003629 (2013); Supplementary Information
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Oocyte differentiation is genetically dissociable from meiosis in mice
Dokshin GA, Baltus AE, Eppig JJ, Page DC
Nat Genet 45, 877 (2013); Supplementary Information
Okumura LM, Lesch BJ, Page DC
PLOS ONE 8, e66062 (2013)
TALEN-mediated editing of the mouse Y chromosome
Wang H, Hu YC, Markoulaki S, Welstead GG, Cheng AW, Shivalila CS, Pyntikova T, Dadon DB, Voytas DF, Bogdanove AJ, Page DC, Jaenisch R
Nat Biotechnol 31, 530 (2013); Supplementary Information
Intrachromosomal homologous recombination between inverted repeat amplicons on opposing Y-chromosome arms.
Lange J, Noordam MJ, van Daalen SK, Skaletsky H, Clark BA, Macville MV, Page DC, Repping S
Genomics 102, 257 (2013); Supplementary Information
2012
AZFc deletions and spermatogenic failure: A population-based survey of 20,000 Y chromosomes.
Rozen S, Marszalek JD, Irenze K, Skaletsky H, Brown LG, Oates RD, Silber SJ, Ardlie K, Page DC
Am J Hum Genet 91, 890 (2012); Supplementary Information
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Sequencing of rhesus macaque Y chromosome clarifies origins and evolution of the DAZ (Deleted in AZoospermia) genes.
Hughes JF, Skaletsky H, Page DC
Bioessays 34, 1035 (2012); Supplementary Information
Genetics of germ cell development.
Lesch BJ, Page DC
Nat Rev Genet 13, 781 (2012)
Direct reprogramming of fibroblasts into embryonic Sertoli-like cells by defined factors.
Buganim Y, Itskovich E, Hu YC, Cheng AW, Ganz K, Sarkar S, Fu D, Welstead G, Page DC, Jaenisch R
Cell Stem Cell 11, 373 (2012); Supplementary Information
Identification of avian W-linked contigs by short-read sequencing
Chen N, Bellott DW, Page DC, Clark AG
BMC Genomics 13, 183 (2012)
Genomics and genetics of human and primate Y chromosomes
Hughes JF, Rozen S
Annu Rev Genomics Human Genet 13, 83 (2012)
Germ cell pluripotency, premature differentiation and susceptibility to testicular teratomas in mice
Heaney JD, Anderson EL, Michelson MV, Zechel JL, Conrad PA, Page DC, Nadeau JH
Development 139, 1577 (2012); Supplementary Information
Strict evolutionary conservation followed rapid gene loss on human and rhesus Y chromosomes
Hughes JF, Skaletsky H, Brown LG, Pyntikova T, Graves TA, Fulton RS, Dugan S, Ding Y, Buhay CJ, Kremitzki C, Wang Q, Shen H, Holder M, Villasana D, Nazareth LV, Cree A, Courtney L, Veizer J, Kotkiewicz H, Cho T, Koutseva N, Rozen S, Muzny DM, Warren WC, Gibbs RA, Wilson RK, Page DC
Nature 483, 82 (2012); Supplementary Information
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What we don't know about sexual reproduction
Page DC
Bulletin of the American Academy of Arts & Sciences, Winter, (2012)
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2011
Mir-290-295 deficiency in mice results in partially penetrant embryonic lethality and germ cells defects
Medeiros LA, Dennis LM, Gill ME, Houbaviy H, Markoulaki S, Fu D, White AC, Kirak O, Sharp PA, Page DC, Jaenisch R
PNAS 108, 14163 (2011); Supplementary Information
Tet1 is dispensable for maintaining pluripotency and its loss is compatible with embryonic and postnatal development
Dawlaty MM, Ganz K, Powell BE, Hu YC, Markoulaki S, Cheng AW, Gao Q, Kim J, Choi SW, Page DC, Jaenisch R
Cell Stem Cell 9(2), 166 (2011); Supplementary Information
Licensing of gametogenesis, dependent on RNA binding protein DAZL, as a gateway to sexual differentiation of fetal germ cells
Gill ME, Hu Y, Lin Y, Page DC
PNAS 108, 7443 (2011); Supplementary Information
Let's remember the chromosomes
Page DC
Cell 147, 9 (2011)
2010
Convergent evolution of chicken Z and human X chromosomes by expansion and gene acquisition
Bellott DW, Skaletsky H, Pyntikova T, Mardis ER, Graves T, Kremitzki C, Brown LG, Rozen S, Warren WC, Wilson RK, Page DC
Nature 466, 612 (2010); Supplementary Information
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Chimpanzee and human Y chromosomes are remarkably divergent in structure and gene content
Hughes JF, Skaletsky H, Pyntikova T, Graves TA, van Daalen SK, Minx PJ, Fulton RS, McGrath SD, Locke DP, Friedman C, Trask BJ, Mardis ER, Warren WC, Repping S, Rozen S, Wilson RK, Page DC
Nature 463, 536 (2010); Supplementary Information
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2009
Loss of YY1 impacts the heterochromatic state and meiotic double-strand breaks during mouse spermatogenesis
Wu S, Hu YC, Liu H, Shi Y
Mol Cell Biol 29, 6245 (2009)
Rozen S, Marszalek JD, Alagappan RK, Skaletsky H, Page DC
American Journal of Human Genetics 85, 923 (2009); Supplementary Information
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Isodicentric Y chromosomes and sex disorders as byproducts of homologous recombination that maintains palindromes
Lange J, Skaletsky H, van Daalen SK, Embry SL, Korver CM, Brown LG, Oates RD, Silber S, Repping S, Page DC
Cell 138, 855 (2009); Supplementary Information
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Reconstructing the evolution of vertebrate sex chromosomes
Bellott DW, Page DC
Cold Spring Harb Symp on Quant Biol 74, 345 (2009)
2008
Germ cell–intrinsic and –extrinsic factors govern meiotic initiation in mouse embryos
Lin Y, Gill ME, Koubova J, Page DC
Science 322, 1685 (2008); Supplementary Information
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Stra8 and its inducer, retinoic acid, regulate meiotic initiation in both spermatogenesis and oogenesis in mice
Anderson E, Baltus AE, Roepers-Gajadien HL, Hassold TJ, de Rooij DG, van Pelt AMM, Page DC
PNAS 105, 14876 (2008)
The mouse X chromosome is enriched for multicopy testis genes showing postmeiotic expression
Mueller JL, Mahadevaiah SK, Park PJ, Warburton PE, Page DC, Turner JM
Nat Genet 40, 794 (2008); Supplementary Information
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Meiotic failure in male mice lacking an X-linked factor
Yang F, Gull K, van Heijden GW, Eckardt S, Leu NA, Page DC, Benavente R, Her C, Hoog C, McLaughlin KJ, Wang PJ
Genes Dev 22, 682 (2008); Supplementary Information
MSY Breakpoint Mapper, a database of sequence-tagged sites useful in defining naturally occurring deletions in the human Y chromosome
Lange J, Skaletsky H, Bell GW, Page DC
Nucleic Acids Res 36, D809 (2008)
2007
Abnormal sperm in mice lacking the Taf7l gene
Cheng Y, Buffone MG, Kouadio M, Goodheart M, Page DC, Gerton GL, Davidson I, Wang PJ
Mol Cell Biol 27, 2582 (2007); Supplementary Information
The mysteries of sexual identity: the germ cell's perspective
Kimble J and Page DC
Science 316, 400, (2007)
2006
In germ cells of mouse embryonic ovaries, the decision to enter meiosis precedes premeiotic DNA replication
Baltus AE, Menke DB, Hu Y, Goodheart ML, Carpenter AE, de Rooij DG, Page DC
Nat Genet 38, 1430 (2006); Supplementary Information
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High mutation rates have driven widespread architectural polymorphism among human Y chromosomes
Repping S, van Daalen SKM, Brown LG, Korver CM, Lange J, Marszalek JD, Pyntikova T, van der Veen F, Skaletsky H, Page DC, Rozen S
Nat Genet 38, 463 (2006); Supplementary Information
Retinoic acid regulates sex-specific timing of meiotic initiation in mice
Koubova J, Menke DB, Zhou Q, Capel B, Griswold MD, Page DC
PNAS 103, 2474 (2006); Supplementary Information
Has the chimpanzee Y chromosome been sequenced?
Hughes JF, Skaletsky H, Rozen S, Wilson RK, Page DC
Nat Genet 38, 853 (2006); Supplementary Information
2005
Dazl deficiency leads to embryonic arrest of germ cell development in XY C57BL/6 mice
Lin Y, Page DC
Dev Biol 288, 309 (2005); Supplementary Information
Hughes JF, Skaletsky H, Pyntikova T, Minx PJ, Graves T, Rozen S, Wilson RK, Page DC
Nature 437, 100 (2005); Supplementary Information
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Differential expression of sex-linked and autosomal germ-cell-specific genes during spermatogenesis in the mouse
Wang PJ, Page DC, McCarrey JR
Hum Mol Genet 14, 2911 (2005)
RNF17, a component of the mammalian germ cell nuage, is essential for spermiogenesis
Pan J, Goodheart M, Chuma S, Nakatsuji N, Page DC, Wang PJ
Development 132, 4029 (2005)
2004
Are sequence family variants useful for identifying deletions in the human Y chromosome?
Repping S, Korver CM, Oates RD, Silber S, van der Veen F, Page DC, Rozen S
Am J Hum Genet 75, 514 (2004)
An X-to-autosome retrogene is required for spermatogenesis in mice
Bradley J, Baltus A, Skaletsky H, Royce-Tolland M, Dewar K, Page DC
Nat Genet 36, 872 (2004); Supplementary Information
A family of human Y chromosomes has dispersed throughout northern Eurasia despite a 1.8-Mb deletion in the Azoospermia Factor c region
Repping S, van Daalen KM, Korver CM, Brown LG, Marszalek JD, Gianotten J, Oates RD, Silber S, van der Veen F, Page DC, Rozen S
Genomics 83, 1046 (2004)
Follistatin operates downstream of Wnt4 in mammalian ovary organogenesis
Yao HH, Matzuk MM, Jorgez CJ, Menke DB, Page DC, Swain A, Capel B
Dev Dyn 230, 210 (2004)
Wt1 functions in the development of germ cells in addition to somatic cell lineages of the testis
Natoli TA, Alberta JA, Bortvin A, Taglienti ME, Menke DB, Loring J, Jaenisch R, Page DC, Housman DE, Kreidberg JA
Dev Biol 268, 429 (2004)
Dppa3 / Pgc7 / stella is a maternal factor and is not required for germ cell specification in mice
Bortvin A, Goodheart M, Liao M, Page DC
BMC Dev Biol 4 2, (2004)
Curt Stern Award address: On low expectations exceeded; or, the genomic salvation of the Y chromosome
Page DC
Am J Hum Genet 74, 399 (2004)
2003
Sexual differentiation of germ cells in XX mouse gonads occurs in an anterior-to-posterior wave
Menke DB, Koubova J, Page DC
Dev Biol 262, 303 (2003)
Polymorphism for a 1.6-Mb deletion of the human Y chromosome persists through balance between recurrent mutation and haploid selection
Repping S, Skaletsky H, Brown L, van Daalen SK, Korver CM, Pyntikova T, Kuroda-Kawaguchi T, de Vries JW, Oates RD, Silber S, van der Veen F, Page DC, Rozen S
Nat Genet 35, 247 (2003); Supplementary Information
The pituitary-testicular axis in Klinefelter's syndrome and in oligo-azoospermic patients with and without deletions of the Y chromosome long arm
Tomasi PA, Oates R, Brown L, Delitala G, Page DC
Clin Endocrinol (Oxford) 59, 214 (2003)
Abundant gene conversion between arms of palindromes in human and ape Y chromosomes
Rozen S, Skaletsky H, Marszalek JD, Minx PJ, Cordum HS, Waterston RH, Wilson RK, Page DC
Nature 423, 873 (2003); Supplementary Information
The male-specific region of the human Y chromosome is a mosaic of discrete sequence classes
Skaletsky H, Kuroda-Kawaguchi T, Minx PJ, Cordum HS, Hillier L, Brown LG, Repping S, Pyntikova T, Ali J, Bieri T, Chinwalla A, Delehaunty A, Delehaunty K, Du H, Fewell G, Fulton L, Fulton R, Graves T, Hou SF, Latrielle P, Leonard S, Mardis E, Maupin R, McPherson J, Miner T, Nash W, Nguyen C, Ozersky P, Pepin K, Rock S, Rohlfing T, Scott K, Schultz B, Strong C, Tin-Wollam A, Yang SP, Waterston RH, Wilson RK, Rozen S, Page DC
Nature 423, 825 (2003); Supplementary Information
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Incomplete reactivation of Oct4-related genes in mouse embryos cloned from somatic nuclei
Bortvin A, Eggan K, Skaletsky H, Akutsu H, Berry DL, Yanagimachi R, Page DC, Jaenisch R
Development 130, 1673 (2003)
Velocardiofacial syndrome in an unexplained XX male
Phelan MC, Rogers RC, Crawford EC, Brown LG, Page DC
Am J Med Genet A 116A, 77 (2003)
2002
Sexually dimorphic gene expression in the developing mouse gonad
Menke DB, Page DC
Gene Expr Patterns 2, 359 (2002); Supplementary Information
Clinical characterization of 42 oligospermic or azoospermic men with microdeletion of the AZFc region of the Y chromosome, and of 18 children conceived via ICSI
Oates RD, Silber S, Brown LG, Page DC
Hum Reprod 17, 2813 (2002)
Recombination between palindromes P5 and P1 on the human Y chromosome causes massive deletions and spermatogenic failure
Repping S, Skaletsky H, Lange J, Silber S, van der Veen F, Oates RD, Page DC, Rozen S
Am J Hum Genet 71, 906 (2002)
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Functional substitution for TAF(II)250 by a retroposed homolog that is expressed in human spermatogenesis
Wang PJ, Page DC
Hum Mol Genet 11, 2341 (2002)
Previously uncharacterized histone acetyltransferases implicated in mammalian spermatogenesis
Lahn BT, Tang ZL, Zhou J, Barndt RJ, Parvinen M, Allis CD, Page DC
PNAS 99, 8707 (2002)
2001
Jaruzelska J, Korcz A, Wojda A, Jedrzejczak P, Bierla J, Surmacz T, Pawelczyk L, Page DC, Kotecki M
J Med Genet 38, 798 (2001)
The AZFc region of the Y chromosome features massive palindromes and uniform recurrent deletions in infertile men
Kuroda-Kawaguchi T, Skaletsky H, Brown LG, Minx PJ, Cordum HS, Waterston RH, Wilson RK, Silber S, Oates R, Rozen S, Page DC
Nat Genet 29, 279 (2001); Supplementary Information
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Two closely related human nuclear RNA export factors utilize entirely distinct export pathways
Yang J, Bogerd, HP, Wang PJ, Page DC, Cullen BR
Mol Cell 8, 397 (2001)
An abundance of X-linked genes expressed in spermatogonia
Wang PJ, McCarrey JR, Yang F, Page DC
Nat Genet 27, 422 (2001); Supplementary Information
A physical map of the human Y chromosome
Tilford CA, Kuroda-Kawaguchi T, Skaletsky H, Rozen S, Brown LG, Rosenberg M, McPherson JD, Wylie K, Sekhon M, Kucaba TA, Waterston RH, Page DC
Nature 409, 943 (2001); Supplementary Information
2000
Primer3 on the WWW for general users and for biologist programmers.
Rozen S, Skaletsky H
Methods Mol Biol. 132, 365 (2000)
DAZ family proteins exist throughout male germ cell development and transit from nucleus to cytoplasm at meiosis in humans and mice
Reijo RA, Dorfman DM, Slee R, Renshaw AA, Loughlin KR, Cooke H, Page DC
Biol Reprod 63, 1490 (2000)
Sun C, Skaletsky H, Rozen S, Gromoll J, Nieschlag E, Oates R, Page DC
Hum Mol Genet 9, 2291 (2000)
Optical mapping of BAC clones from the human Y chromosome DAZ locus
Giacalone J, Delobette S, Gibaja V, Ni L, Skiadas Y, Qi R, Edington J, Lai Z, Gebauer D, Zhao H, Anantharaman T, Mishra B, Brown LG, Saxena R, Page DC, Schwartz DC
Genome Res 10, 1421 (2000)
Unexpectedly similar rates of nucleotide substitution found in male and female hominids
Bohossian HB, Skaletsky H, Page DC
Nature 406, 622 (2000)
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Four DAZ genes in two clusters found in the AZFc region of the human Y chromosome
Saxena R, de Vries JW, Repping S, Alagappan RK, Skaletsky H, Brown LG, Ma P, Chen E, Hoovers JM, Page DC
Genomics 67, 256 (2000)
The human UTY gene encodes a novel HLA-B8-restricted H-Y antigen
Warren EH, Gavin MA, Simpson E, Chandler P, Page DC, Disteche C, Stankey KA, Greenberg PD, Riddell SR
J Immunol 164, 2807 (2000)
Dazl protein expression in adult rat testis is up-regulated at meiosis and not hormonally regulated
Rocchietti-March M, Weinbauer GF, Page DC, Nieschlag E, Gromoll J
Intl J Androl 23, 51 (2000)
A human sex-chromosomal gene family expressed in male germ cells and encoding variably charged proteins
Lahn BT, Page DC
Hum Mol Genet 9, 311 (2000)
Detailed mapping, mutation analysis, and intragenic polymorphism identification in candidate Noonan syndrome genes MYL2, DCN, EPS8, and RPL6
Ion A, Crosby AH, Kremer H, Kenmochi N, van Reen M, Fenske C, van der Burgt I, Brunncer HG, Montgomery K, Kucherlapati RS, Patton MA, Page C, Mariman E, Jeffrey S
J Med Genet 37, 884 (2000)
1999
An azoospermic man with a de novo point mutation in the Y-chromosomal gene USP9Y
Sun C, Skaletsky H, Birren B, Devon K, Tang Z, Silber S, Oates R, Page DC
Nat Genet 23, 429 (1999)
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Four evolutionary strata on the human X chromosome
Lahn BT, Page DC
Science 286, 964 (1999)
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Gromoll J, Weinbauer GF, Skaletsky H, Schlatt S, Rocchietti-March M, Page DC, Nieschlag E
Hum Mol Genet 8, 2017 (1999)
Page DC, Silber S, Brown LG
Hum Reprod 14, 1722 (1999)
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A region of human chromosome 9p required for testis development contains two genes related to known sexual regulators
Raymond CS, Parker ED, Kettlewell JR, Brown LG, Page DC, Kusz K, Jaruzelska J, Reinberg Y, Flejter WL, Bardwell VJ, Hirsch B, Zarkower D
Hum Mol Genet 8, 989 (1999)
Retroposition of autosomal mRNA yielded testis-specific gene family on human Y chromosome
Lahn BT, Page DC
Nat Genet 21, 429 (1999)
1998
Y chromosome deletions in azoospermic and severely oligozoospermic men undergoing intracytoplasmic sperm injection after testicular sperm extraction
Silber SJ, Alagappan R, Brown LG, Page DC
Hum Reprod 13, 3332 (1998)
Jegalian K, Page DC
Nature 394, 776 (1998)
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The Dazh gene is expressed in male and female embryonic gonads before germ cell sex differentiation
Seligman J, Page DC
Biochem Biophys Res Commun 245, 878 (1998)
A map of 75 human ribosomal protein genes
Kenmochi N, Kawaguchi T, Rozen S, Davis E, Goodman N, Hudson TJ, Tanaka T, Page DC
Genome Res 8, 509 (1998)
Reconstructing hominid Y evolution: X-homologous block, created by X-Y transposition, was disrupted by Yp inversion through LINE-LINE recombination
Schwartz A, Chan DC, Brown LG, Alagappan R, Pettay D, Disteche C, McGillivray B, de la Chapelle A, Page DC
Hum Mol Genet 7, 1 (1998)
We're off to see the genome
Reilly PR, Page DC
Nat Genet 20, 15 (1998)
1997
Functional coherence of the human Y chromosome
Lahn BT, Page DC
Science 278, 675 (1997)
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Abnormal XY interchange between a novel isolated protein kinase gene, PRKY, and its homologue, PRKX, accounts for one third of all (Y+)XX males and (Y-)XY females
Schiebel K, Winkelmann M, Mertz A, Xu X, Page DC, Weil D, Petit C, Rappold GA
Hum Mol Genet 6, 1985 (1997)
Zfx mutation results in small animal size and reduced germ cell number in male and female mice
Luoh SW, Bain PA, Polakiewicz RD, Goodheart ML, Gardner H, Jaenisch R, Page DC
Development 124, 2275 (1997)
Intron/exon structure confirms that mouse Zfy1 and Zfy2 are members of the ZFY gene family
Mahaffey CL, Bayleran JK, Yeh GY, Lee TC, Page DC, Simpson EM
Genomics 41, 123 (1997)
Expression of DAZ, an azoospermia factor candidate, in human spermatogonia
Menke DB, Mutter GL, Page DC
Am J Hum Genet 60, 237 (1997)
Azoospermic men with deletion of the DAZ gene cluster are capable of completing spermatogenesis: fertilization, normal embryonic development and pregnancy occur when retrieved testicular spermatozoa are used for intracytoplasmic sperm injection
Mulhall JP, Reijo R, Alagappan R, Brown L, Page D, Carson R, Oates RD
Hum Reprod 12, 503 (1997)
Save the males!
Page DC
Nat Genet 17, 3 (1997)
1996
Saxena R, Brown LG, Hawkins T, Alagappan RK, Skaletsky H, Reeve MP, Reijo R, Rozen S, Dinulos MB, Disteche CM, Page DC
Nat Genet 14, 292 (1996)
A gene map of the human genome
Schuler GD, Boguski, MS, Stewart EA, Stein LD, Gyapay G, Rice K, White RE, Rodriguez-Tome P, Aggarwal A, Bajorek E, Bentolila S, Birren BB, Butler A, Castle AB, Chiannilkulchai N, Chu A, Clee C, Cowles S, Day, PJR, Dibling T, Drouot N, Dunham I, Duprat S, East C, Edwards C, Fan J.-B, Fang N, Fizames C, Garrett C, Green L, Hadley D, Harris M, Harrison P, Brady S, Hicks A, Holloway E, Hui L, Hussaine S, Louis-Dit-Sully C, Ma J, MacGilvery A, Mader C, Maratukulam A, Matise TC, McKusick KB, Morissette J, Mungall A, Muselet D, Nusbaum HC, Page DC, Peck A, Perkins S, Piercy M, Qin F, Quackenbush J, Ranby S, Reif T, Rozen S, Sanders C, She X, Silva J, Slonim DK, Soderlund C, Sun W-L, Tabar P, Thangarajah T, Vega-Czarny N, Vollrath D, Voyticky S, Wilmer T, Wu X, Adams MD, Auffray C, Berry R, Brandon R, Dehejia A, Goodfellow PN, Houlgatte R, Hudson Jr. JR, Ide SE, Iorio KR, Lee WY Seki N, Nagase T, Ishikawa K, Nomura N, Phillips C, Polymeropoulos MH, Sandusky M, Schmitt K, Sikela JM, Swanson K, Torres R, Venter JC, Walter NAR, Beckmann JS, Weissenbach, J, Myers RM, Cox DR, James MR, Bentley D, Deloukas P, Lander ES, Hudson TJ
Science 274, 540 (1996)
Sex-determining genes on mouse autosomes identified by linkage analysis of C57BL/6J-YPOS sex reversal
Eicher EM, Washburn LL, Schork NJ, Lee BK, Shown EP, Xu X, Dredge RD, Pringle MJ, Page DC
Science 274, 540 (1996)
Mouse autosomal homolog of DAZ, a candidate male sterility gene in humans, is expressed in male germ cells before and after puberty
Reijo R, Seligman J, Dinulos MB, Jaffe T, Brown LG, Disteche CM, Page DC
Genomics 35, 346 (1996)
Severe oligozoospermia resulting from deletions of azoospermia factor gene on Y chromosome
Reijo R, Alagappan RK, Patrizio P, Page DC
Lancet 347, 1290 (1996)
1995
Mapping of ribosomal protein S3 and internally nested snoRNA U15A gene to human chromosome 11q13.3-q13.5
Polakiewicz RD, Munroe DJ, Sait SNJ, Tycowski KT, Nowak NJ, Shows TB, Howsman DE, Page DC
Genomics 25, 577 (1995)
Molecular mapping of the putative gonadoblastoma locus on the Y chromosome
Salo P, Kääriäinen H, Petrovic V, Peltomäki P, Page DC, de la Chapelle A
Genes Chromosomes Cancer 14, 210 (1995)
Integration of transcript and genetic maps of chromosome 16 at near-1-Mb resolution: Demonstration of a "hot spot"
Callen DF, Lane SA, Kozman H, Kremmidiotis G, Whitmore SA, Lowenstein M, Doggett NA, Kenmochi N, Page DC, Maglott DR, Nierman WC, Murakawa K, Berry R, Sikela JM, Houlgatte R, Auffray C, Sutherland GR
Genomics 29, 503 (1995)
Gonadoblastoma- molecular definition of the susceptibility region on the Y chromosome
Tsuchiya K, Reijo R, Page DC, Disteche CM
Am J Hum Genet 57, 1400 (1995)
Dysgerminoma and gonadal fysgenesis in a 46,XX female with no evidence of Y chromosomal DNA
Letterie GS, Page DC
Gynecol Oncol 57, 423 (1995)
Diverse spermatogenic defects in humans caused by Y chromosome deletions encompassing a novel RNA-binding protein gene
Reijo R, Lee TY, Salo P, Alagappan R, Brown LG, Rosenberg M, Rozen S, Jaffe T, Straus D, Hovatta O, de la Chapelle A, Silber S, Page DC
Nat Genet 10, 383 (1995)
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Deletion mapping of stature determinants on the long arm of the Y chromosome
Salo P, Kääriäinen H, Page DC, de la Chapelle A
Hum Genet 95, 283 (1995)
CpG islands in human ZFX and ZFY and mouse Zfx Genes: Sequence similarities and methylation differences
Luoh SW, Jegalian K, Lee A, Chen EY, Ridley A, Page DC
Genomics 29, 353 (1995)
Characterization of a YAC contig spanning the pseudoautosomal region
Ried K, Mertz A, Nagaraja R, Trusgnich M, Riley JH, Anand R, Lehrach H, Page D, Ellison JW, Rappold G
Genomics 29, 787 (1995)
An STS-based map of the human genome
Hudson TJ, Stein LD, Gerety SS, Ma J, Castle AB, Silva J, Slonim DK, Baptista R, Kruglyak L, Xu SH, Hu X, Colbert AM, Rosenberg C, Reeve-Daly MP, Rozen S, Hui L, Wu X, Vestergaard C, Wilson KM, Bae JS, Maitra S, Ganiatsas S, Evans CA, DeAngelis MM, Ingalls KA, Nahf RW, Horton LT Jr, Anderson MO, Collymore AJ, Ye W, Kouyoumjian V, Zemsteva IS, Tam J, Devine R, Courtney DF, Renaud MT, Nguyen H, O'Connor TJ, Fizames C, Faurâ S, Gyapay G, Dib C, Morissette J, Orlin JB, Birrne BW, Goodman N, Weissenbach J, Hawkins TL, Foote S, Page DC, Lander ES
Science 270, 1945 (1995)
1994
Xq-Yq interchange resulting in supernormal X-linked gene expression in severely retarded males with 46,XYq- karyotype
Lahn BT, Ma N, Breg WR, Stratton R, Surti U, Page DC
Nat Genet 8, 243 (1994)
Structure and function of ribosomal protein S4 genes on the human and mouse sex chromosomes
Zinn AR, Alagappan RK, Brown LG, Wool I, Page DC
Mol Cell Biol 14, 2485 (1994)
Ovary? Testis? -- A mammalian dilemma
Bogan JS, Page DC
Cell 76, 603 (1994)
Y chromosome sequences in Turner syndrome and risk of gonadoblastoma or virilisation
Page DC
Lancet 343, 240 (1994)
The structure of the Zfx gene on the mouse X chromosome
Luoh SW, Page DC
Genomics 19, 310 (1994)
Multipoint linkage map of the human pseudoautosomal region, based on single-sperm typing- do double crossovers occur during male meiosis
Schmitt K, Lazzeroni LC, Foote S, Vollrath D, Fisher EM, Goradia TM, Lange K, Page DC, Arnheim N
Am J Hum Genet 55, 3 (1994)
Expression of a mouse Zfy-1-lacZ transgene in the somatic cells of the embryonic gonad and germ cells of the adult testis
Zambrowicz BP, Zimmermann JW, Harendza CJ, Simpson EM, Page DC, Brinster RL, Palmiter RD
Development 120, 1549 (1994)
A genetic map of the mouse with 4,006 simple sequence length polymorphisms
Dietrich WF, Miller JC, Steen RG, Merchant M, Damron D, Nahf R, Gross A, Joyce DC, Wessel M, Dredge RD, Marquis A, Stein LD, Goodman N, Page DC, Lander ES
Nat Genet 7, 220 (1994)
1993
Four PCR-based polymorphisms in the pseudoautosomal region of the human X and Y chromosomes
Schmitt K, Vollrath D, Foote S, Fisher EM, Page DC, Arnheim N
Hum Mol Genet 2, 1978 (1993)
Evidence that the SRY protein is encoded by a single exon on the human Y chromosome
Behlke MA, Bogan JS, Beer-Romero P, Page DC
Genomics 17, 736 (1993)
Watanabe M, Zinn AR, Page DC, Nishimoto T
Nat Genet 4, 268 (1993)
Turner syndrome: the case of the missing sex chromosome
Zinn AR, Page DC, Fisher EM
Trends Genet 9, 90 (1993)
1992
The human Y chromosome: a 43-interval map based on naturally occurring deletions
Vollrath D, Foote S, Hilton A, Brown LG, Beer-Romero P, Bogan JS, Page DC
Science 258, 52 (1992)
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Rps4 maps near the inactivation center on the mouse X chromosome
Hamvas RM, Zinn A, Keer JT, Fisher EM, Beer-Romero P, Brown SD, Page DC
Genomics 12, 363 (1992)
The human Y chromosome: overlapping DNA clones spanning the euchromatic region
Foote S, Vollrath D, Hilton A, Page DC
Science 258, 60 (1992)
Lindgren V, Chen CP, Bryke CR, Lichter P, Page DC, Yang-Feng TL
Hum Genet 88, 393 (1992)
1991
Inactivation of the Rps4 gene on the mouse X chromosome
Zinn AR, Bressler SL, Beer-Romero P, Adler DA, Chapman VM, Page DC, Disteche CM
Genomics 11, 1097 (1991)
An interstitial deletion in mouse Y chromosomal DNA created a transcribed Zfy fusion gene
Simpson EM, Page DC
Genomics 11, 601 (1991)
Hassold TJ, Sherman SL, Pettay D, Page DC, Jacobs PA
Am J Hum Genets 49, 253 (1991)
Inactivation of the Zfx gene on the mouse X chromosome
Adler DA, Bressler SL, Chapman VM, Page DC, Disteche CM
PNAS 88, 4592 (1991)
1990
Additional deletion in sex-determining region of human Y chromosome resolves paradox of X,t(Y;22) female
Page DC, Fisher EM, McGillivray B, Brown LG
Nature 346, 279 (1990)
Chromosomal localization of ZFX--a human gene that escapes X inactivation--and its murine homologs
Page DC, Disteche CM, Simpson EM, de la Chapelle A, Andersson M, Alitalo T, Brown LG, Green P, Akots G
Genomics 7, 37 (1990)
Homologous ribosomal protein genes on the human X and Y chromosomes- escape from X inactivation and possible implications for Turner syndrome
Fisher EM, Beer-Romero P, Brown LG, Ridley A, McNeil JA, Lawrence JB, Willard HF, Bieber FR, Page DC
Cell 63, 1205 (1990)
Human sex-chromosome-specific repeats within a region of pseudoautosomal/Yq homology
Fisher EM, Alitalo T, Luoh S-W, de la Chapelle A, Page DC
Genomics 7, 625 (1990)
Mouse Zfx protein is similar to Zfy-2- each contains an acidic activating domain and 13 zinc fingers
Mardon G, Luoh SW, Simpson EM, Gill G, Brown LG, Page DC
Mol Cell Biol 10, 681, (1990)
Steroid sulfatase gene in XX males
Mohandas TK, Stern HJ, Meeker CA, Passage MB, Müller U, Page DC, Yen PH, Shapiro LJ
Am J Hum Genet 46, 369 (1990)
1989
An extremely polymorphic locus on the short arm of the human X chromosome with homology to the long arm of the Y chromosome
Knowlton RG, Nelson CA, Brown VA, Page DC, Donis-Keller H
Nucleic Acids Res 17, 423 (1989)
Duplication, deletion, and polymorphism in the sex-determining region of the mouse Y chromosome
Mardon G, Mosher R, Disteche CM, Nishioka Y, McLaren A, Page DC
Science 243, 78 (1989)
Haplotype and multipoint linkage analysis in Finnish choroideremia families
Sankila EM, Lehner T, Eriksson AW, Forsius H, Kärnä J, Page D, Ott J, de la Chapelle A
Human Genetics 84, 66 (1989)
Molecular analysis of 46,XY females and regional assignment of a new Y-chromosome-specific probe
Cantrell MA, Bicknell JN, Pagon RA, Page DC, Walker DC, Saal HM, Zinn AB, Disteche CM
Hum Genet 83, 88 (1989)
Putative transcription activator with alternative isoforms encoded by human ZFX gene
Schneider-Gädicke A, Beer-Romero P, Brown LG, Mardon G, Luoh SW, Page DC
Nature 342, 708 (1989)
The sex-determining region of the mouse Y chromosome encodes a protein with a highly acidic domain and 13 zinc fingers
Mardon G, Page DC
Cell 56, 765 (1989)
ZFX has a gene structure similar to ZFY, the putative human sex determinant, and escapes X inactivation
Schneider-Gädicke A, Beer-Romero P, Brown LG, Nussbaum R, Page DC
Cell 57, 1247 (1989)
Ullrich-Turner syndrome in an XY female fetus with deletion of the sex-determining portion of the Y chromosome
Blagowidow N, Page DC, Huff D, Mennuti MT
Am J Med Genet 34, 159 (1989)
Molecular evidence of Y-autosomal translocations in owl monkeys
Ma NS, Page DC, Harris TS
J Hered 80, 259 (1989)
1988
Characterization of a (Y;4) translocation by DNA hybridization
Andersson M, Page DC, Brown LG, Elfving K, de la Chapelle A
Hum Genet 78, 377 (1988)
Molecular detection of a Yp/18 translocation in a 45,X holoprosencephalic male
Münke M, Page DC, Brown LG, Armson BA, Zackai EH, Mennuti MT, Emanuel BS
Hum Genet 80, 219 (1988)
Schwartz M, Yang HM, Niebuhr E, Rosenberg T, Page DC
Hum Genet 78, 156 (1988)
Sequences homologous to ZFY, a candidate human sex-determining gene, are autosomal in marsupials
Sinclair AH, Foster JW, Spencer JA, Page DC, Palmer M, Goodfellow PN, Graves JA
Nature 336, 780 (1988)
The parental origin and mechanism of formation of three dicentric X chromosomes
Phelan MC, Prouty LA, Stevenson RE, Howard-Peebles PN, Page DC, Schwartz CE
Hum Genet 80, 81 (1988)
XX true hermaphroditism in southern African blacks- an enigma of primary sexual differentiation
Ramsay M, Bernstein R, Zwane E, Page DC, Jenkins T
Am J Hum Genet 43, 4 (1988)
Andersson M, Page DC, Pettay D, Subrt I, Turleau C, de Grouchy J, de la Chapelle A
Hum Genet 79, 2 (1988)
Genetic mapping of the Wiskott-Aldrich syndrome with two highly-linked polymorphic DNA markers
Kwan SP, Sandkuyl LA, Blaese M, Kunkel LM, Bruns G, Parmley R, Skarshaug S, Page DC, Ott J, Rosen FS
Genomics 3, 39 (1988)
Is ZFY the sex-determining gene on the human Y chromosome?
Page DC
Philos Trans R Soc Lond B Biol Sci 322, 155 (1988)
1987
A 45,X male with Y-specific DNA translocated onto chromosome 15
Gal A, Weber B, Neri G, Serra A, Müller U, Schempp W, Page DC
Am J Hum Genet 40, 477 (1987)
An XXX male resulting from paternal X-Y interchange and maternal X-X nondisjunction
Annerén G, Andersson M, Page DC, Brown LG, Berg M, Läckgren G, Gustavson KH, de la Chapelle A
Am J Hum Genet 41, 594 (1987)
A sex chromosome rearrangement in a human XX male caused by Alu-Alu recombination
Rouyer F, Simmler MC, Page DC, Weissenbach J
Cell 51, 417 (1987)
A unique dicentric X;Y translocation with Xq and Yp breakpoints- cytogenetic and molecular studies
Bernstein R, Rosendorff J, Ramsay M, Pinto MR, Page DC
Am J Hum Genet41, 145, (1987)
Exchange of terminal portions of X- and Y-chromosomal short arms in human XX males
Page DC, Brown LG, de la Chapelle A
Nature 328, 437 (1987)
Linkage of an X-chromosome cleft palate gene
Moore GE, Ivens A, Chambers J, Farrall M, Williamson R, Page DC, Bjornsson A, Arnason A, Jensson O
Nature 326, 91 (1987)
Simpson E, Chandler P, Goulmy E, Disteche CM, Ferguson-Smith MA, Page DC
Nature 326, 876 (1987)
The sex-determining region of the human Y chromosome encodes a finger protein
Page DC, Mosher R, Simpson EM, Fisher EM, Mardon G, Pollack J, McGillivray B, de la Chapelle A, Brown LG
Cell 51, 1091 (1987)
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Page DC, Bieker K, Brown LG, Hinton S, Leppert M, Lalouel JM, Lathrop M, Nystrom-Lahti M, de la Chapelle A, White R
Genomics 1, 243 (1987)
Mapping the H-Y gene
Simpson E, Chandler P, McLaren A, Goulmy E, Disteche CM, Page DC, Ferguson-Smith MA
Development 101 (Suppl), 157 (1987)
Hypothesis: a Y-chromosomal gene causes gonadoblastoma in dysgenetic gonads
Page DC
Development 101 (Suppl), 151 (1987)
1986
A deletion map of the human Y chromosome based on DNA hybridization
Vergnaud G, Page DC, Simmler MC, Brown L, Rouyer F, Noel B, Botstein D, de la Chapelle A, Weissenbach J
Am J Hum Genet 38, 109 (1986)
Chromosome Y-specific DNA is transferred to the short arm of X chromosome in human XX males
Andersson M, Page DC, de la Chapelle A
Science 233, 786 (1986)
Molecular detection of a translocation (Y;15) in a 45,X male
Disteche CM, Brown L, Saal H, Friedman C, Thuline HC, Hoar DI, Pagon RA, Page DC
Hum Genet 74, 372 (1986)
Small deletions of the short arm of the Y chromosome in 46,XY females
Disteche CM, Casanova M, Saal H, Friedman C, Sybert V, Graham J, Thuline H, Page DC, Fellous M
PNAS 83, 7841 (1986)
de la Chapelle A, Page DC, Brown L, Kaski U, Parvinen T, Tippett PA
Am J Hum Genet 38, 330 (1986)
Sex reversal: deletion mapping the male-determining function of the human Y chromosome
Page DC
Cold Spring Harb Symp Quant Biol 51, 229 (1986)
1985
Chromosome Y-specific DNA in related human XX males
Page DC, de la Chapelle A, Weissenbach J
Nature 315, 224 (1985)
1984
Genetic evidence of X-Y interchange in a human XX male
de la Chapelle A, Tippett PA, Wetterstrand G, Page D
Nature 307, 170 (1984)
Page DC, Harper ME, Love J, Botstein D
Nature 311, 119 (1984)
Putney S, Herlihy W, Royal N, Pang H, Aposhian HV, Pickering L, Belagaje R, Biemann K, Page D, Kuby S, et al
J Biol Chem 259, 14317 (1984)
Page DC, de la Chapelle A
Am J Hum Genet 36, 565 (1984)
1982
Single-copy sequence hybridizes to polymorphic and homologous loci on human X and Y chromosomes
Page D, de Martinville B, Barker D, Wyman A, White R, Francke U, Botstein D
PNAS 79, 5352 (1982)
1980
Core histone associations in solutions of high salt. An osmotic pressure study
Stein A, Page D
J Biol Chem 255, 3629 (1980)